Tony Natale, M.D.

Tony Natale, M.D.

Managing Partner

Aperture Venture Partners

Tony Natale, M.D. blends his extensive business, investment and company formation experience with a background in clinical medicine. Dr. Natale has invested across a number of therapeutic areas, including orthopedics, ENT, ophthalmology, cardiology, GI, minimally invasive technologies, neurostim, robotics and women’s health. A committed board member, Dr. Natale works alongside entrepreneurs to build out management teams, establish effective corporate governance and bring operational discipline to R&D and early commercialization efforts. 

Dr. Natale was previously with Prism Ventures and MDS Capital where he made and managed investments in the life sciences sector. He has been a founder, director and/or lead investor of many venture-backed life sciences companies, including Mako Surgical, XLumena, Spirox, Otonomy, Entrigue Surgical, Channel Medsystems, Inspire Medical, Lyric Pharmaceutical, Cardiac Dimensions, Venus Concept, Neuros Medical, Avedro and Resonant Medical. 

Dr. Natale trained in General Surgery and Otolaryngology/Head and Neck Surgery at the University of Connecticut and Hartford Hospital before transitioning into entrepreneurial activities. He holds a B.A., Phi Beta Kappa, from the University of Virginia, an M.D. from the University of Florida and an M.B.A. from Yale.